Recent advances in carbocupration of α-heterosubstituted alkynes

• Ahmad Basheer and
• Ilan Marek

Beilstein J. Org. Chem. 2010, 6, No. 77, doi:10.3762/bjoc.6.77

• change the stereochemical outcome of the reaction. Representative examples are given in this mini-review. Keywords: alkynes; carbocupration; enamides; regioselectivity; stereoselectivity; syn-addition; vinylcopper; ynamides; ynol ether; Review The addition of a carbon-metal bond of an organometallic

• was employed in the two-directional synthesis of the F-J fragment of Gambieric Acid [17]. On the other hand, when substituted ynol ether 7 (R and R1 = alkyl) was treated with the same organocopper reagents under the same conditions, the two substituents flanking the triple bond have opposite effects